Council of Scientific and Industrial Research, Ministry of Science and Technology, GOI
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Regulatory Toxicological Studies


Mammalian Toxicity Assessment:

  • In vitro Cyto-toxicity, Genotoxicity and Anti-Oxidant assays are routinely done with various cell lines.
  • Acute, Repeated and Sub-Chronic Toxicological studies are being conducted by oral and dermal routes following OECD guidelines for nano materials, pesticides, natural products etc with special reference to haematological, biochemical, histopathology and genotoxicity parameters.

Anti-rodent and Anti-Squirrel testing

  • Anti-rodent choice and no-choice studies in laboratory and in field conditions are conducted periodically on three species of wild rodents according to Bharat Sanchar Nigam Limited/IICT protocols for Indian/Foreign industries as well as for Indian Defence Organizations. Similarly anti-squirrel facility for field choice and no-choice has been set up to test the drip irrigation pipes/wires/tubes etc. and provide the detail test reports for their safety.

Facilities Available in Toxicology

  • GLP accredited Animal House facilities for conducting various toxicological studies.
  • Available Instruments.
  • Field Antirodent Enclosure.

UV-Visible Spectrophotometer

Ultra Centrifuge

Deep Freezer

Fluorescence Microscope

Tissue Processor

Tissue Embedder


Light Microscope

Slide Stainer

Anti-rodent testing Enclosure

Genetic toxicity screening of newer molecules/drugs/products

The compound that poses positive Genetic toxicity are mostly carcinogenic or mutagenic in nature. These studies are mostly used for rapid identification of hazardous compounds for New Chemical Entities (NCE) that causes DNA damage. Genetic toxicity tests are very low cost and highly reliable. Mostly damages are observed as gene mutation, structural chromosomal aberrations, recombination and hypo-hyperploidy. Most of these chromosomal changes may lead to cancer and if it is found in the germline cells leads to heritable damages to next generation through gamets. Hence, compounds should be tested for genotoxicity potential thoroughly before it expose to organism.

Battery of genetic toxicology tests for chemical compounds includes:

In vitro cytogenetic assays

  • MTT assays using cell lines
  • cell cycle assay
  • Chromosomal aberration test
  • Mitotic index study
  • Micronucleus test
  • Comet assay (single cell gel electrophoresis)

In vivo genotoxicity assay

On somatic cell

  • Chromosomal aberration test
  • Micronucleus test
  • Mitotic index study
  • Comet assay (single cell gel electrophoresis)

On Germline cells

  • Spermatogonial chromosomal assay (gonad: testis)
  • Spermatocyte chromosomal assay (gonad: testis)
  • Sperm head morphology test

Screening of bio-efficacy studies

  • Antimicrobial studies
  • Mosquito larvicidal and adulticidal studies
  • Mosquito larvicidal and adulticidal studies
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