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Chemical Biology

History

Chemical biology Division was envisioned in the 10th Five Year Plan (FYP). CSIR-IICT has established the Chemical Biology facility of 30,000 sft building with basic infrastructure for executing preliminary small molecule screening against cancer, CNS and cardiovascular diseases in the XI FYP with an aim to optimally utilize the synthetic chemistry efforts of the institute by linking biological screening of the molecules and understanding their mode of action in further developing new therapeutic leads.

The Facility for Chemical Biology was accorded the full division status and was renamed as Centre for Chemical biology (CCB) in the year 2012. Since inception, CCB has played instrumental role in the identification of bioactive compounds at IICT and about 150 papers have been published so far in collaborative research. Presently the Division is executing a 12th FYP program, SMiLE (Small Molecule in Lead Exploration) to convert the hits obtained from high-throughput screens into leads. The centre has also established various platforms for performing both basic and applied biological research and offers capabilities with multiple systems and has access to a collection of small molecule compound libraries. CSIR-IICT has a large resource of chemical expertise and these capabilities are complemented by CCB expertise in assay development, HTS, molecular biology genetics, structural biology, toxicology and molecular modelling studies. In addition, CCB also executes several individual projects funded by DST, DBT and ICMR and are recipient of prestigious fellowship awards such as Wellcome Trust, Ramanujan and Ramalinga Swamy.

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