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Medicinal Chemistry & Pharmacology

Pharmacology

The Pharmacology group was established in the year 1983 in the division of Medicinal Chemistry (Organic Chemistry -1) to strengthen the New Drug Development Programme in this Institute. This group initially used to identify biologically active molecules by primary and secondary screening of the newly synthesized compounds. The pharmacological active compounds for analgesic , anti-inflammatory, hypolipidemic , hypoglycemic, anti-hypertensive , anticancer , anti-spasmating and anti microbial activities were screened. The lead/ active compound thus identified was further taken up for toxicity and tertatological studies. Toxicological studies: acute and chronic (60-180 days) toxicity studies were carried out in the laboratory animals such as mice, rats, rabbits, guinea pigs and dogs. This group is also carrying out pharmacokinetic and pharmacodynamic studies to understand the absorption and mechanism of action of the new molecules developed. Few promising compounds have been identified and these molecules are taken up to clinical studies (4003/2).

Presently, the areas of expertise of the Pharmacology Division can be broadly divided into Pharmacological evaluation, Novel Drug Delivery Systems (NDDS) and Regulatory Toxicology. Apart from general pharmacological evaluations, emphasis is also focused to develop natural products as well as functional foods to meet the epidemic of metabolic disorders particularly type II diabetes mellitus and obesity.

The Division also focuses on the development of New Drug Delivery Systems (NDDS), their characterization and pharmacodynamic and pharmacokinetic performance in suitable animal models.

The division has the expertise and is fully equipped instruments for conducting the toxicity studies on the NCEs in the drug development phase (Regulatory Toxicology). Expertise is available for in conducting acute, sub chronic and chronic toxicity studies employing OECD guidelines. In additions, in vitro micronucleus assays and chromosomal aberration studies are being undertaken. The Pharmacology group now caters to the need of in-house R&D and Pharmaceutical industries.

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